If your ego ever shoved a chile in your maw that was hotter than your mouth could handle, you learned something very fast: capsaicin loves to piss off pain receptors. Some of us have even learned this lesson twice; once on eating the chile, again when it says good bye on the way out. What you may not know is that capsaicin keeps up the shenanigans all the way through your digestive system, all the way from point A to B. That pain is the basis of research suggesting that chile peppers may prevent colon cancer.